By Dennis Thompson
HealthDay Reporter
HealthDay Reporter
FRIDAY, June 6, 2014
(HealthDay News) — Cleanliness may be next to godliness, but a home
that’s too clean can leave a newborn child vulnerable to allergies and
asthma later in life, a new study reports.
Infants are much less likely to
suffer from allergies or wheezing if they are exposed to household
bacteria and allergens from rodents, roaches and cats during their first
year of life, the study found.
The results stunned
researchers, who had been following up on earlier studies that found an
increased risk of asthma among inner-city dwellers exposed to high
levels of roach, mouse and pet droppings and allergens.
“What we found was somewhat
surprising and somewhat contradictory to our original predictions,” said
study co-author Dr. Robert Wood, chief of the Division of Allergy and
Immunology at the Johns Hopkins Children’s Center in Baltimore. “It
turned out to be completely opposite — the more of those three allergens
you were exposed to, the less likely you were to go on to have wheezing
or allergy.”
About 41 percent of
allergy-free and wheeze-free children in the study grew up in homes that
were rich with allergens and bacteria. By contrast, only 8 percent of
children who suffered from both allergy and wheezing had been exposed to
these substances in their first year of life.
The findings support the
“hygiene hypothesis,” which holds that children in overly clean houses
are more apt to suffer allergies because their bodies don’t have the
opportunity to develop appropriate responses to allergens, said Dr. Todd
Mahr, an allergist-immunologist in La Crosse, Wis., and chair of the
American Academy of Pediatrics’ Section on Allergy & Immunology.
Prior research has shown that
children who grow up on farms have lower allergy and asthma rates,
possibly due to their regular exposure to bacteria and microbes, the
researchers noted in background material.
“The environment appears to
play a role, and if you have too clean of an environment the child’s
immune system is not going to be stimulated,” Mahr explained.
As many as half of all
3-year-olds in the United States suffer from wheezing illnesses, and
recurrent wheezing and allergies are considered a risk factor for asthma
in later life, researchers said. According to the American Lung
Association, asthma remains one of the most common pediatric illnesses,
affecting about 7 million American children.
The new study involved 467
inner-city newborns from Baltimore, Boston, New York and St. Louis.
Doctors enrolled the babies in the study while they were still in the
womb, and have been tracking their health since birth, Wood said.
Investigators visited the
infants’ homes to measure the levels and types of allergens. They also
collected dust in about a quarter of the homes and analyzed its
bacterial content.
They found that infants who
grew up in homes with mouse and cat dander and cockroach droppings in
the first year of life had lower rates of wheezing at age 3, compared
with children not exposed to the allergens.
Wheezing was three times as
common among children who grew up without exposure to such allergens,
affecting 51 percent of children in “clean” homes compared with 17
percent of children who spent their first year of life in houses where
all three allergens were present.
Household bacteria also played a
role, and infants in homes with a greater variety of bacteria were less
likely to develop allergies and wheezing by age 3.
Children free of wheezing and
allergies at age 3 had grown up with the highest levels of household
allergens and were the most likely to live in houses with the richest
array of bacterial species, researchers found.
“The combination of both —
having the allergen exposure and the bacterial exposure — appeared to be
the most protective,” Wood said.
Both Wood and Mahr cautioned
that these findings need to be verified, and that parents shouldn’t make
any household decisions based on them.
For example, parents shouldn’t
adopt a dog or cat assuming that its presence will help immunize their
kids against allergies and asthma, Wood said. At the same time, they
shouldn’t ditch their family pet, either.
“We would not take any of this
as information we could use to give advice,” Wood said. “Please don’t
get an intentional cockroach infestation in your house. There’s no
reason to think that would help.”
There are a number of other
factors that could influence the likelihood that an inner-city kid will
develop asthma, including tobacco smoke, high levels of household
stress, or even exposure to the same sort of potentially beneficial
allergens too late in life, past their first birthday, Wood said.
“This is by no means a simple story,” he said. “There could be a lot of factors going on.”
Mahr said the findings could
someday lead to treatments that would help infants build up resistance
to allergies. “I can see someone coming up with a spray. You’d spray the
crib that the kid sleeps in every so often, and let the kid crawl
around in it,” he said.
More information
Find out more about indoor allergens at the American Academy of Allergy, Asthma & Immunology.
Post a Comment